Combination of serum TIMP-3, CA125, and NT-proBNP in predicting ventricular remodeling in patients with heart failure following acute myocardial infarction
| Autor: | Hai-Bo Wu, Guang Liu, Qian-Hui Zhang, Yue-Tao Xie, Fei-Fei Zhang, Yi Dang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Heart failure Internal medicine cardiovascular system medicine Cardiology Serum ca125 Original Article In patient cardiovascular diseases Myocardial infarction Cardiology and Cardiovascular Medicine Ventricular remodeling business Pathological Left ventricular wall |
| Zdroj: | Cardiovasc Diagn Ther |
| ISSN: | 2223-3660 2223-3652 |
| DOI: | 10.21037/cdt-20-399 |
| Popis: | BACKGROUND: Left ventricular remodeling is the basic pathological mechanism of heart failure following acute myocardial infarction (AMI). Determining sensitive indexes for the early prediction of ventricular remodeling is important for the prevention of heart failure. This study aims to investigate the value of serum TIMP-3, CA125, and NT-proBNP in predicting ventricular remodeling in patients with heart failure following AMI. METHODS: From May 2017 to May 2018, 93 patients with heart failure following AMI were enrolled in the study. The participants were divided into two groups: the ventricular remodeling group (n=51) and the non-ventricular remodeling group (n=42). In addition, 47 healthy subjects who underwent physical examinations in the same period were enrolled as controls. Serum TIMP-3, CA125, and NT-proBNP were measured, in addition to the left ventricular wall thickness (LVWT) and left ventricular mass index (LVMI). The correlation of serum TIMP-3, CA125, and NT-proBNP with the LVWT and LVMI was analyzed, and its value in predicting ventricular remodeling was evaluated. RESULTS: Serum TIMP-3 level was lower (P |
| Databáze: | OpenAIRE |
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