Sex differences in the temperature dependence of kidney stone presentations: a population-based aggregated case-crossover study
| Autor: | Ana M. Vicedo-Cabrera, Robert E. Kopp, David S. Goldfarb, Gregory E. Tasian, Lihai Song |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Hot Temperature Climate Change South Carolina Urology 030232 urology & nephrology Cumulative Exposure Population based Article Kidney Calculi Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Prevalence Humans Medicine Private insurance Aged Cross-Over Studies business.industry Middle Aged Symptom Flare Up medicine.disease Crossover study Sexual dimorphism Relative risk Female Kidney stones Emergency Service Hospital business Heat-Shock Response Demography |
| Zdroj: | Urolithiasis |
| ISSN: | 2194-7236 2194-7228 |
| DOI: | 10.1007/s00240-019-01129-x |
| Popis: | BACKGROUND: Previous studies assumed a uniform relationship between heat and kidney stone presentations. Determining whether sex and other characteristics modify the temperature-dependence of kidney stone presentations has implications for explaining differences in nephrolithiasis prevalence and improving projections of the effect of climate change on nephrolithiasis. METHODS: We performed an aggregated case-crossover study among 132,597 children and adults who presented with nephrolithiasis to 68 emergency departments throughout South Carolina from 1997-2015. We used quasi-Poisson regression with distributed lag non-linear models to estimate sex differences in the cumulative exposure- and lagged-response between maximum daily wet-bulb temperatures and emergent kidney stone presentations, aggregated at the ZIP-code level. We also explored interactions by age, race, payer, and climate. RESULTS: Compared to 10°C, daily wet-bulb temperatures at the 99(th) percentile were associated with a greater increased relative risk (RR) of kidney stone presentations over 10 days for males (RR 1.73; 95% CI: 1.56, 1.91) than for females (RR 1.15; 95% CI: 1.01, 1.32; interaction P |
| Databáze: | OpenAIRE |
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