The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats
| Autor: | Ronaldo C. Araujo, Taia Maria Berto Rezende, Richard W.A. Mackenzie, Ivo Vieira de Sousa Neto, Keemilyn K S Silva, Azize Yildirim, Claudia Stela Medeiros, Rita de Cássia Marqueti, Ana Paula C. Cantuária, Octavio L. Franco, Leandro Ceotto Freitas-Lima, Jeeser Alves de Almeida |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment Adipokine Adipose tissue Inflammation High-protein diet Intra-Abdominal Fat Weight Gain medicine.disease_cause Article 03 medical and health sciences chemistry.chemical_compound Adipocyte Internal medicine Adipocytes Animals Medicine TX341-641 Rats Wistar adipokines Cell Size Epididymis 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply business.industry Resistance Training Organ Size Metabolism Glutathione Diet 030104 developmental biology Endocrinology Cytokine chemistry Diet High-Protein dietary management Insulin Resistance medicine.symptom Adipocyte hypertrophy business exercise training metabolism Food Science |
| Zdroj: | Nutrients Volume 13 Issue 6 Nutrients, Vol 13, Iss 1969, p 1969 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13061969 |
| Popis: | High-protein diets (HPDs) are widely accepted as a way to stimulate muscle protein synthesis when combined with resistance training (RT). However, the effects of HPDs on adipose tissue plasticity and local inflammation are yet to be determined. This study investigated the impact of HPDs on glucose control, adipocyte size, and epididymal adipose inflammatory biomarkers in resistance-trained rats. Eighteen Wistar rats were randomly assigned to four groups: normal-protein (NPD 17% protein total dietary intake) and HPD (26.1% protein) without RT and NPD and HPD with RT. Trained groups received RT for 12 weeks with weights secured to their tails. Glucose and insulin tolerance tests, adipocyte size, and an array of cytokines were determined. While HPD without RT induced glucose intolerance, enlarged adipocytes, and increased TNF-α, MCP-1, and IL1-β levels in epididymal adipose tissue (p < 0.05), RT diminished these deleterious effects, with the HPD + RT group displaying improved blood glucose control without inflammatory cytokine increases in epididymal adipose tissue (p < 0.05). Furthermore, RT increased glutathione expression independent of diet (p < 0.05). RT may offer protection against adipocyte hypertrophy, pro-inflammatory states, and glucose intolerance during HPDs. The results highlight the potential protective effects of RT to mitigate the maladaptive effects of HPDs. |
| Databáze: | OpenAIRE |
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