Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults
| Autor: | Cristina Menni, Tim D. Spector, Harold Snieder, Massimo Mangino, Gail Clement, Feng Zhang, Sandosh Padmanabhan |
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| Přispěvatelé: | Life Course Epidemiology (LCE) |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Physiology POWER Diastole Blood Pressure heritability 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences 0302 clinical medicine DESIGN Genetic variation Internal Medicine Humans Medicine 030304 developmental biology 0303 health sciences business.industry twins Middle Aged Heritability Twin study United Kingdom EPISODIC HYPERTENSION Confidence interval 3. Good health Phenotype Blood pressure Cohort Female blood pressure variability Cardiology and Cardiovascular Medicine business Cohort study Demography |
| Zdroj: | Journal of Hypertension, 31(12), 2356-2361. LIPPINCOTT WILLIAMS & WILKINS Journal of Hypertension; Vol 31 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0b013e32836523c1 |
| Popis: | Background: Clinic and long-term average blood pressure (BP) are heritable traits with estimates of heritability ranging from 0.31 to 0.68. Long-term visit-to-visit BP variability (BPV) is emerging as a new cardiovascular risk predictor, though it is unclear if this is completely independent of BP. We hypothesize that BPV should demonstrate the same pattern of additive genetic, shared environmental and unique environmental variance as BP, if both are phenotypic surrogates. Method: We studied 2889 twin pairs not on any BPlowering therapy from the Twins UK cohort, and estimated the additive genetic variance for baseline BP, long-term average BP, BP trajectory (rate of change of BP in mmHg/ year) and BPV (coefficient of variation and average real variability over an average of 3.2 visits). Heritability estimates were obtained by structural equation modelling adjusting for age, age 2 , sex and BMI. Results: The heritabilities for baseline SBP and DBP were 0.51 (95% confidence interval 0.49, 0.53) and 0.56 (0.54, 0.58); long-term average SBP and DBP were 0.56 (0.53, 0.59) and 0.61 (0.58, 0.64); and systolic and diastolic trajectories over 10 years were 0.49 (0.46, 0.52) and 0.29 (0.27, 0.32), respectively. Both overall systolic and diastolic BPV showed no additive genetic variance contributing to the phenotypic variation, but after stratification by age, the younger subgroup ( |
| Databáze: | OpenAIRE |
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