Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters
| Autor: | Rachel A. Sattler, Shinji Urata, Megumi Kishimoto-Urata, Slobodan Paessler, Nantian Lin, Junki Maruyama, Tatsuya Yamasoba, Tomoko Makishima, Rebecca S. Cook |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nasal cavity
Olfactory system Pathology medicine.medical_specialty Letter Physiology Anosmia Cognitive Neuroscience Turbinates Biochemistry Olfactory Receptor Neurons olfactory dysfunction 03 medical and health sciences Olfactory mucosa 0302 clinical medicine Olfactory Mucosa Animals Regeneration Medicine Nasal Turbinate Nasal Septum 030304 developmental biology 0303 health sciences Mesocricetus biology SARS-CoV-2 business.industry COVID-19 Organ Size Cell Biology General Medicine biology.organism_classification Disease Models Animal medicine.anatomical_structure olfactory epithelium Nasal Cavity medicine.symptom business Olfactory epithelium 030217 neurology & neurosurgery |
| Zdroj: | ACS Chemical Neuroscience |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.0c00649 |
| Popis: | Olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (COVID-19). Information on the damage and repair of the neuroepithelium and its impact on olfactory function after COVID-19 is still incomplete. While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the ongoing worldwide outbreak of COVID-19, little is known about the changes triggered by SARS-CoV-2 in the olfactory epithelium (OE) at the cellular level. Here, we report profiles of the OE after SARS-CoV-2 infection in golden Syrian hamsters, which is a reliable animal model of COVID-19. We observed severe damage in the OE as early as 3 days postinoculation and regionally specific damage and regeneration of the OE within the nasal cavity; the nasal septal region demonstrated the fastest recovery compared to other regions in the nasal turbinates. These findings suggest that anosmia related to SARS-CoV-2 infection may be fully reversible. |
| Databáze: | OpenAIRE |
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