Potential metabolic and behavioural roles of the putative endocannabinoid receptors gpr18, gpr55 and gpr119 in feeding
| Autor: | Paula Morales, Carlos M. Villalón, J. Rafael Villafan-Bernal, Ricardo Ernesto Ramírez-Orozco, Ricardo García-Ruiz, Bruno A. Marichal-Cancino |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cannabinoid receptor Endocannabinoid system medicine.medical_treatment Biology Article Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Mediator medicine Animals Humans Pharmacology (medical) Receptors Cannabinoid Receptor G protein-coupled receptor Pharmacology Cannabinoids General Medicine Psychiatry and Mental health 030104 developmental biology Neurology GPR55 GPR119 GPR18 lipids (amino acids peptides and proteins) Neurology (clinical) Cannabinoid Neuroscience 030217 neurology & neurosurgery Endocannabinoids Feeding control |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Current Neuropharmacology |
| ISSN: | 1875-6190 |
| Popis: | Endocannabinoids are ancient biomolecules involved in several cellular (e.g., metabolism) and physiological (e.g., eating behaviour) functions. Indeed, eating behaviour alterations in marijuana users have led to investigate the orexigenic/anorexigenic effects of cannabinoids in animal/ human models. This increasing body of research suggests that the endocannabinoid system plays an important role in feeding control. Accordingly, within the endocannabinoid system, cannabinoid receptors, enzymes and genes represent potential therapeutic targets for dealing with multiple metabolic and behavioural dysfunctions (e.g., obesity, anorexia, etc.). Paradoxically, our understanding on the endocannabinoid system as a cellular mediator is yet limited. For example: (i) only two cannabinoid receptors have been classified, but they are not enough to explain the pharmacological profile of several experimental effects induced by cannabinoids; and (ii) several orphan G protein-coupled receptors (GPCRs) interact with cannabinoids and we do not know how to classify them (e.g., GPR18, GPR55 and GPR119; amongst others). : On this basis, the present review attempts to summarize the lines of evidence supporting the potential role of GPR18, GPR55 and GPR119 in metabolism and feeding control that may explain some of the divergent effects and puzzling data related to cannabinoid research. Moreover, their therapeutic potential in feeding behaviour alterations will be considered. |
| Databáze: | OpenAIRE |
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