Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia
| Autor: | Iman H. Al-Sheikh, Naglaa Fawaz, Wassim Y. Almawi, Sara Al-Othman, Layla Bashawery, Ahlam Qatari |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty Pediatrics Adolescent DNA Mutational Analysis Saudi Arabia Anemia Sickle Cell Thrombophilia Gastroenterology hemic and lymphatic diseases Internal medicine Genotype medicine Factor V Leiden Humans Risk factor Child Methylenetetrahydrofolate Reductase (NADPH2) biology business.industry Homozygote Factor V Hematology Middle Aged medicine.disease Sickle cell anemia Hemoglobinopathy Methylenetetrahydrofolate reductase Mutation biology.protein Prothrombin G20210A Female Prothrombin business |
| Zdroj: | American Journal of Hematology. 76:307-309 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.20087 |
| Popis: | The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single-point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications. Am. J. Hematol. 76:307–309, 2004. © 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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