Elevated Exhaled Nitric Oxide in Newborns of Atopic Mothers Precedes Respiratory Symptoms
| Autor: | David N. Baldwin, Urs Frey, Carmen Casaulta, Claudia E. Kuehni, Philipp Latzin, Hanna L. Roiha |
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| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Allergy medicine.medical_specialty Nitric Oxide Critical Care and Intensive Care Medicine Pregnancy Risk Factors Wheeze Intensive care Internal medicine Hypersensitivity Humans Medicine Prospective Studies Respiratory system Asthma business.industry Smoking Respiratory disease Infant Newborn Infant medicine.disease Pregnancy Complications Breath Tests Relative risk Exhaled nitric oxide Immunology Regression Analysis Female medicine.symptom business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 174:1292-1298 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200606-782oc |
| Popis: | Exhaled nitric oxide (NO) is a well-known marker of established airway inflammation in asthma. Its role in the disease process before the onset of respiratory symptoms remains unclear.To examine whether elevated NO in newborns with clinically naive airways is associated with subsequent respiratory symptoms in infancy.We measured exhaled NO concentration and output after birth and prospectively assessed respiratory symptoms during infancy in a birth cohort of 164 unselected healthy neonates. We examined a possible association between NO and respiratory symptoms using Poisson regression analysis.In infants of atopic mothers, elevated NO levels after birth were associated with increased risk of subsequent respiratory symptoms (risk ratio [RR], 7.5; 95% confidence interval [CI], 1.7-32.4 for each nl/s increase in NO output; p = 0.007). Similarly, a positive association between NO and symptoms was seen in infants of smoking mothers (RR, 6.6; 95% CI, 2.3-19.3; p = 0.001), with the strongest association in infants whose mothers had both risk factors (RR, 21.8; 95% CI, 5.8-81.3; p0.001).The interaction of NO with maternal atopy and smoking on subsequent respiratory symptoms is present early in life. Clinically, noninvasive NO measurements in newborns may prove useful as a new means to identify high-risk infants. Future confirmation of a role for NO metabolism in the evolution of respiratory disease may provide an avenue for preventative strategies. |
| Databáze: | OpenAIRE |
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