Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism
| Autor: | James W. Tetrud, François Vingerhoets, Donald B. Calne, Barry J. Snow, J. William Langston, Vesna Sossi |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Parkinson's disease Substantia nigra Striatum Pharmacology Central nervous system disease chemistry.chemical_compound Degenerative disease Dopamine medicine Humans Fluorodopa Parkinson Disease Secondary Lewy body business.industry MPTP Parkinsonism Dopaminergic Middle Aged medicine.disease Corpus Striatum nervous system diseases Editorial Commentary Psychiatry and Mental health nervous system chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Papers Female Surgery Neurology (clinical) Psychology business Neuroscience medicine.drug Tomography Emission-Computed |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 68:313-316 |
| ISSN: | 0022-3050 |
| Popis: | Objectives—To examine the distribution of striatal dopaminergic function in humans with parkinsonism induced by 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP) to determine if there is a caudateputamen gradient as is seen in idiopathic Parkinson’s disease. Methods—We scanned nine humans exposed to MPTP with parkinsonism ranging from minimal to severe using [ 18 F]fluorodopa (FD) and high resolution PET. The results were compared with those of 10 patients with Parkinson’s disease and six normal subjects. Results—In the MPTP group there was an equal degree of reduction of dopaminergic function in the caudate and putamen.This was diVerent from the greater putaminal than caudate loss in Parkinson’s disease (p |
| Databáze: | OpenAIRE |
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