ENDOCRINE FUNCTION IN THALASSAEMIA
| Autor: | R. Suwanik, Sathit Vannasaeng, S. Ploybutr, P. Visutkul, P. Wasi, Tandhanand S |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Glucose loading Endocrinology Diabetes and Metabolism Urinary system medicine.medical_treatment Thyroid Gland Sexual immaturity Endocrinology Internal medicine Adrenal Glands medicine Humans Endocrine system Child Growth Disorders business.industry Insulin Glucose Tolerance Test Thailand Growth hormone secretion Growth Hormone Pituitary Gland Thalassemia Female Thyroid function business Serum cortisol |
| Zdroj: | Clinical Endocrinology. 14:165-173 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1981.tb00612.x |
| Popis: | SUMMARY Twenty-one Thai patients with β-thalassaemia/haemoglobin E and haemoglobin H diseases, 8–20-years-old, were studied. These patients had received none or minimal blood transfusions. The important clinical endocrine abnormalities were growth retardation and sexual immaturity. GH secretion was found to be impaired in the majority of patients. Oral GTT showed chemical diabetes in one out of sixteen tested, a much lower incidence than in thalassaemic patients treated by hypertransfusion in the West. The mean insulin levels basally and after glucose loading were lower than those of the normal controls. Thyroid function was normal in all the patients. Serum cortisol and 24-h urinary oxogenic steroids (17 OGS) levels were normal, as was adrenal cortical reserve in all the patients. The literature on endocrine function in thalassaemia is reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text