A group of glycosphingolipids found in an invertebrate: Their structures and biological significance
| Autor: | Mei Satake, Eishichi Miyamoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Nervous system
neurobiological functions tissue distribution Molecular Sequence Data General Physics and Astronomy Review Biology Nervous System Glycolipid Aplysia medicine Side chain Animals Protein kinase A Aplysia kurodai glycosphingolipids chemical structures Nervous tissue Water General Medicine biology.organism_classification Cyclic AMP-Dependent Protein Kinases carbohydrates (lipids) medicine.anatomical_structure Biochemistry Carbohydrate Sequence Solubility Biological significance lipids (amino acids peptides and proteins) General Agricultural and Biological Sciences |
| Zdroj: | Proceedings of the Japan Academy. Series B, Physical and Biological Sciences |
| ISSN: | 1349-2896 0386-2208 |
| Popis: | A novel group of glycosphingolipids was identified in the nervous tissue and skin of the mollusc, Aplysia kurodai, which lacks gangliosides. More than 30 glycolipids were detected on HPTLC plates and the structures of 9 major glycolipids were determined. They were pentaosylglycosphingolipids and their common core structure was GalNAcα1→3Galβ1→4Glcβ1→1ceramide, except for one glycolipid in which Galβ of the core structure was replaced by Galα. 3-O-MeGalβ or 4-O-MeGlcNAcα or 3,4-O-carboxyethylideneGalβ was at their non-reducing ends. Galα or Fucα binds to Gal of the core structure at 2C as a side chain sugar. One to three 2-aminoethylphosphonic acids and/or phosphoethanolamine link to the glycolipids. Immunohistochemically, glycolipids having carboxyethylideneGal at their non-reducing ends were localized exclusively in nerve bundles. Glycolipids activated cAMP-dependent protein kinase in the rat brain and may directly activate cAMP-dependent protein kinase in a manner similar, but not identical, to that of cAMP. The biological functions of glycolipids may share neurobiological functions proposed for gangliosides in vertebrates. |
| Databáze: | OpenAIRE |
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