Biophotonic Ring Resonator for Ultrasensitive Detection of DMMP As a Simulant for Organophosphorus Agents

Autor:	Karine Bonnot, Antonio Varriale, Denis Spitzer, F. Cuesta-Soto, Francisco Lopez-Royo, Nuria Sanchez, Manuel Rodrigo, Sabato D'Auria
Rok vydání:	2014
Předmět:	Chemical Terrorism business.industry Chemistry Photonic integrated circuit Nanotechnology Sarin Analytical Chemistry Resonator Organophosphorus Compounds Microcomputers Chemical Warfare Agents Photonics business Biosensor Environmental Monitoring
Zdroj:	Analytical Chemistry. 86:5125-5130
ISSN:	1520-6882 0003-2700
Popis:	Combining photonic integrated circuits with a biologically based sensing approach has the ability to provide a new generation of portable and low-cost sensor devices with a high specificity and sensitivity for a number of applications in environmental monitoring, defense, and homeland security. We report herein on the specific biosensing under continuous air flow of DMMP, which is commonly used as a simulant and a precursor for the synthesis of Sarin. The proposed technology is based on the selective recognition of the targeted DMMP molecule by specifically modified proteins immobilized on photonic structures. The response of the biophotonic structures shows a high stability and accuracy over 3 months, allowing for the detection in diluted air of DMMP at concentration as low as 35 μg/m(3) (6.8 ppb) in less than 15 min. The performance of the developed technology satisfies most current homeland and military security requirements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c9e77c00c045abfd4d67b43dbfbe2c https://doi.org/10.1021/ac500903s Zobrazit plný text záznamu