Amplified Drug Delivery System with a Pair of Master Keys Triggering Precise Drug Release for Chemo-Photothermal Therapy

Autor:	Sujuan Ye, Longfei Ma, Jihua Zhang, Ronghua Li, Huanong Cheng
Rok vydání:	2022
Předmět:	Drug Liberation Drug Delivery Systems Doxorubicin Photothermal Therapy Cell Line Tumor Neoplasms Humans Nanoparticles DNA Catalytic Hyperthermia Induced Phototherapy Analytical Chemistry
Zdroj:	Analytical Chemistry. 94:11538-11548
ISSN:	1520-6882 0003-2700
Popis:	A versatile drug delivery system (DDS) enabling highly effective and targeting oncotherapy has always been of great significance in medical research. In the development of a stimuli-responsive DDS, compared with a single-factor stimulation DDS, a multifactor activation DDS has higher therapeutic specificity between diseased and normal tissue, but there are challenges in drug-release efficiency and united targeting cancer therapy. Herein, a novel dual-microRNA (dual-miRNA)-mediated 1:N-amplified DDS is fabricated. The gold nanocage (AuNC) was synthesized and used as a carrier. A DNA bridge motif as a nanolock (DNA bridge nanolock) was designed and modified on the surface of AuNCs, which could seal the holes of AuNCs. Using the dual-miRNAs as a pair of master keys, through DNA strand migration and DNAzyme self-assembly, a cell endogenous substance Mg
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c90d6317c15d8997ebebd1813c9fa2 https://doi.org/10.1021/acs.analchem.2c01663 Zobrazit plný text záznamu