Estimated Trans-Lamina Cribrosa Pressure Differences in Low-Teen and High-Teen Intraocular Pressure Normal Tension Glaucoma: The Korean National Health and Nutrition Examination Survey
| Autor: | Hyoung Won Bae, Eun Min Kang, Si Hyung Lee, Gyu Ah Kim, Sang Yeop Lee, Gong Je Seong, Chan Yun Kim, Seung Woo Kwak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Intraocular pressure Eye Diseases genetic structures Glaucoma lcsh:Medicine Blood Pressure Vascular Medicine 0302 clinical medicine Endocrinology Normal tension glaucoma Medicine and Health Sciences Prevalence lcsh:Science education.field_of_study Multidisciplinary Drugs Middle Aged Neurology Hypertension Female Anatomy Research Article Adult medicine.medical_specialty National Health and Nutrition Examination Survey Endocrine Disorders Optic Neuropathy Population education 03 medical and health sciences Ocular System Ophthalmology Republic of Korea medicine Diabetes Mellitus Humans Intraocular Pressure Aged Pharmacology business.industry lcsh:R Biology and Life Sciences Optic Nerve medicine.disease eye diseases Surgery Neuropathy Blood pressure Metabolic Disorders 030221 ophthalmology & optometry lcsh:Q Cerebrospinal fluid pressure sense organs business Body mass index human activities 030217 neurology & neurosurgery Antihypertensives |
| Zdroj: | PLoS ONE, Vol 11, Iss 2, p e0148412 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background To investigate the association between estimated trans-lamina cribrosa pressure difference (TLCPD) and prevalence of normal tension glaucoma (NTG) with low-teen and high-teen intraocular pressure (IOP) using a population-based study design. Methods A total of 12,743 adults (≥ 40 years of age) who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) from 2009 to 2012 were included. Using a previously developed formula, cerebrospinal fluid pressure (CSFP) in mmHg was estimated as 0.55 × body mass index (kg/m2) + 0.16 × diastolic blood pressure (mmHg)—0.18 × age (years)—1.91. TLCPD was calculated as IOP–CSFP. The NTG subjects were divided into two groups according to IOP level: low-teen NTG (IOP ≤ 15 mmHg) and high-teen NTG (15 mmHg < IOP ≤ 21 mmHg) groups. The association between TLCPD and the prevalence of NTG was assessed in the low- and high-teen IOP groups. Results In the normal population (n = 12,069), the weighted mean estimated CSFP was 11.69 ± 0.04 mmHg and the weighted mean TLCPD 2.31 ± 0.06 mmHg. Significantly higher TLCPD (p < 0.001; 6.48 ± 0.27 mmHg) was found in the high-teen NTG compared with the normal group. On the other hand, there was no significant difference in TLCPD between normal and low-teen NTG subjects (p = 0.395; 2.31 ± 0.06 vs. 2.11 ± 0.24 mmHg). Multivariate logistic regression analysis revealed that TLCPD was significantly associated with the prevalence of NTG in the high-teen IOP group (p = 0.006; OR: 1.09; 95% CI: 1.02, 1.15), but not the low-teen IOP group (p = 0.636). Instead, the presence of hypertension was significantly associated with the prevalence of NTG in the low-teen IOP group (p < 0.001; OR: 1.65; 95% CI: 1.26, 2.16). Conclusions TLCPD was significantly associated with the prevalence of NTG in high-teen IOP subjects, but not low-teen IOP subjects, in whom hypertension may be more closely associated. This study suggests that the underlying mechanisms may differ between low-teen and high-teen NTG patients. |
| Databáze: | OpenAIRE |
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