Imaging and 1-day kinetics of intracoronary stem cell transplantation in patients with idiopathic dilated cardiomyopathy
| Autor: | Luka Lezaic, Bojan Vrtovec, Matjaz Sever, Marko Cukjati, Peter Černelč, Aljaz Socan, Petra Kolenc Peitl, Gregor Poglajen |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male Cancer Research medicine.medical_specialty Pathology Cell Survival medicine.medical_treatment 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences Technetium Tc 99m Exametazime 0302 clinical medicine Cell Movement Internal medicine Idiopathic dilated cardiomyopathy Humans Medicine Radiology Nuclear Medicine and imaging business.industry Stem Cells Dilated cardiomyopathy Stem-cell therapy medicine.disease Coronary Vessels Transplantation Kinetics Haematopoiesis medicine.anatomical_structure Coronary vessel Cardiology Molecular Medicine Female Bone marrow Stem cell business Stem Cell Transplantation |
| Zdroj: | Nuclear Medicine and Biology. 43:410-414 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/j.nucmedbio.2015.12.003 |
| Popis: | Background Stem cell transplantation is an emerging method of treatment for patients with cardiovascular disease. There are few studies completed or ongoing on stem cell therapy in patients with idiopathic dilated cardiomyopathy (IDCM). Information on stem cell homing and distribution in the myocardium after transplantation might provide important insight into effectiveness of transplantation procedure. Aim To assess early engraftment, retention and migration of intracoronarily transplanted stem cells in the myocardium of patients with advanced dilated cardiomyopathy of non-ischaemic origin using stem cell labeling with 99m Tc-exametazime (HMPAO). Materials, methods Thirty-five patients with IDCM and advanced heart failure were included in the study. Autologous hematopoietic (CD34 +) stem cells were harvested by peripheral blood apheresis after bone marrow stimulation, labeled with 99m Tc-HMPAO, tested for viability and injected into coronary vessel supplying areas of myocardium selected by myocardial perfusion scintigraphy as dysfunctional yet viable. Imaging was performed 1 h and 18 h after transplantation. Results Myocardial stem cell retention ranged from 0 to 1.44% on early and 0–0.97% on delayed imaging. Significant efflux of stem cells occurred from site of delivery in this time period (p Conclusion Stem cell labeling with 99m Tc-HMPAO is a feasible method for stem cell tracking after transplantation in patients with IDCM. |
| Databáze: | OpenAIRE |
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