Effects of Statins on Renal Outcome in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis
| Autor: | Sikarin Upala, Patompong Ungprasert, Anawin Sanguankeo, Eric L. Knight, Wisit Cheungpasitporn |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Medicine Renal function Disease Kidney urologic and male genital diseases Medical sciences Internal medicine Pathology Humans Medicine cardiovascular diseases Renal Insufficiency Chronic lcsh:Science Multidisciplinary Proteinuria biology business.industry lcsh:R Case-control study nutritional and metabolic diseases Middle Aged medicine.disease female genital diseases and pregnancy complications Treatment Outcome medicine.anatomical_structure Endocrinology Case-Control Studies Meta-analysis HMG-CoA reductase biology.protein Regression Analysis Female lcsh:Q lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom business Publication Bias Research Article Glomerular Filtration Rate Kidney disease |
| Zdroj: | PLoS ONE, Vol 10, Iss 7, p e0132970 (2015) PLoS ONE |
| DOI: | 10.7916/d8cn73ct |
| Popis: | Background: HMG CoA reductase inhibitors (statins) are known to prevent cardiovascular disease and improve lipid profiles. However, the effects of statins on renal outcomes, including decline in estimated glomerular filtration rate (eGFR) and proteinuria in patients with chronic kidney disease (CKD), are controversial. This meta-analysis evaluated the impact of statins on renal outcomes in patients with CKD. Materials and Methods: We comprehensively searched the databases of MEDLINE, EMBASE, and Cochrane Databases. The inclusion criteria were published RCT and cohort studies comparing statin therapy to placebo or active controls in patients with CKD (eGFR |
| Databáze: | OpenAIRE |
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