Chromosome Y loss and drivers of clonal hematopoiesis in myelodysplastic syndrome
| Autor: | Panagiotis Baliakas, Lars Forsberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Genomics Bone Marrow Cells Biology Y chromosome Article 03 medical and health sciences 0302 clinical medicine Chromosome (genetic algorithm) Y Chromosome Humans 030304 developmental biology Medicinsk genetik Aged Genetics Aged 80 and over Chromosome Aberrations 0303 health sciences Cancer och onkologi Chromosomes Human Y Mosaicism Clonal hematopoiesis Klinisk medicin Editorials Hematology Middle Aged Myelodysplastic Syndromes 030220 oncology & carcinogenesis Cancer and Oncology Cytogenetic Analysis Clonal Hematopoiesis Clinical Medicine Medical Genetics |
| Zdroj: | Haematologica |
| ISSN: | 1592-8721 0390-6078 |
| Popis: | Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in hematopoietic cells in men. However, due to the high prevalence of LOY as the sole cytogenetic finding in the healthy older population, differentiating isolated LOY associated with clonal hematologic processes from aging-associated mosaicism can be difficult in the absence of definitive morphological features of disease. In the past, various investigators have proposed that a high percentage of metaphases with LOY is more likely to represent expansion of a clonal myeloid disease-associated population. It is unknown whether the proportion of metaphases with LOY is associated with the incidence of myeloid neoplasia-associated genomic alterations. To address this question, we identified bone marrow samples with LOY as an isolated cytogenetic finding and used targeted next generation sequencing-based molecular analysis to identify common myeloid neoplasia-associated somatic mutations. Among 73 patients with a median age of 75 years (range, 29-90), the percentage of metaphases with LOY was |
| Databáze: | OpenAIRE |
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