Floating Hydrogel with Self-Generating Micro-Bubbles for Intravesical Instillation
| Autor: | Hongqian Guo, Wei Chen, Guangxiang Liu, Jinhui Wu, Qing Zhang, Tingsheng Lin, Yifan Zhang, Junlong Zhuang, Huibo Lian, Yiqiao Hu, Suhan Guo, Wei Wang, Xiaozhi Zhao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Drug
Materials science media_common.quotation_subject thermo-sensitive hydrogel 02 engineering and technology 010402 general chemistry intravesical instillation lcsh:Technology 01 natural sciences Article In vivo floating hydrogel acute bladder injury Intravesical instillation medicine General Materials Science lcsh:Microscopy lcsh:QC120-168.85 media_common Bladder cancer lcsh:QH201-278.5 shaking lcsh:T Interstitial cystitis Heparin 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences lcsh:TA1-2040 Self-healing hydrogels Poloxamer 407 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology lcsh:TK1-9971 Biomedical engineering medicine.drug |
| Zdroj: | Materials, Vol 9, Iss 12, p 1005 (2016) Materials Materials; Volume 9; Issue 12; Pages: 1005 |
| ISSN: | 1996-1944 |
| Popis: | Intravesical instillation is the main therapy for bladder cancer and interstitial cystitis. However, most drug solutions are eliminated from bladder after the first voiding of urine. To solve this problem, we proposed a floating hydrogel with self-generating micro-bubbles as a new delivery system. It floated in urine, avoiding the urinary obstruction and bladder irritation that ordinary hydrogels caused. In this study, we abandoned traditional gas-producing method like chemical decomposition of NaHCO3, and used the foamability of Poloxamer 407 (P407) instead. Through simple shaking (just like shaking SonoVue for contrast-enhanced ultrasound in clinical), the P407 solution will “lock” many micro-bubbles and float in urine as quickly and steadily as other gas producing materials. In vivo release experiments showed that drug was released continually from hydrogel for 10 h during the erosion process. Thus, the residence time of drug in bladder was prolonged and drug efficacy was improved. In vivo efficacy study using rabbit acute bladder injury model showed that prolonged drug residence time in bladder increased the efficiency of heparin in the protection of bladder mucosal permeability. Therefore, our floating hydrogel system with self-generating micro-bubbles was single-component, simply prepared and efficacy enhancing, successfully exempting users from worries on safety and clinical efficiency from bench to bedside. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|