Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke
| Autor: | Jaouad Loulidi, Davide Poglia, Roman Sztajzel, Fabienne Perren, Theodor Landis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Sulfur Hexafluoride Infarction Tissue plasminogen activator Tissue Plasminogen Activator/therapeutic use Brain ischemia Internal medicine Ultrasonography Doppler Color medicine Humans Thrombolytic Therapy cardiovascular diseases Ultrasonography Doppler Color Stroke Sulfur Hexafluoride/diagnostic use/therapeutic use Phospholipids Aged Microbubbles business.industry Ultrasound Infarction Middle Cerebral Artery Hematology Thrombolysis medicine.disease ddc:616.8 Transcranial Doppler Tissue Plasminogen Activator Cardiology Female Radiology Phospholipids/diagnostic use/therapeutic use Cardiology and Cardiovascular Medicine business Infarction Middle Cerebral Artery/drug therapy/ultrasonography Perfusion medicine.drug |
| Zdroj: | Journal of Thrombosis and Thrombolysis, Vol. 25, No 2 (2008) pp. 219-23 |
| ISSN: | 0929-5305 |
| Popis: | BACKGROUND: We studied whether 2 MHz transcranial color-coded duplex ultrasound (TCCD), combined with a second generation ECA, accelerate IV rtPA-thrombolysis in the acute phase of MCA stroke more than TCCD monitoring alone. METHODS: Non-randomized acute MCA stroke patients undergoing IV rtPA-thrombolysis and 2 MHZ-TCCD monitoring over 60 min, with (N = 11) or without (N = 15) additional continuous ECA (5 ml, SonoVue perfusion, were compared. Recanalization of the MCA was measured pre- and post-thrombolysis with the thrombolysis in brain ischemia (TIBI) grading system, clinical outcome was assessed at admission and 24 h after treatment using the NIH stroke scale (NIHSS). RESULTS: Patients who received ECA improved their NIHSS significantly more than those who were only TCCD monitored (Mann-Whitney U = 48.0; P = 0.050), and their flow signal improved more (Mann-Whitney U = 40.0; P < 0.03). CONCLUSIONS: The results of this pilot study show that in IV-thrombolysis the use of ECA in addition to TCCD monitoring lead to a greater immediate clinical improvement and to a better flow signal. |
| Databáze: | OpenAIRE |
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