SARS-CoV-2 viral-load distribution reveals that viral loads increase with age: a retrospective cross-sectional cohort study
| Autor: | Claudia van Gemeren, Erik Kapteijns, Alex Wagemakers, James Cohen Stuart, Dominic Snijders, Sjoerd M. Euser, Ruud Jansen, Dennis Souverein, Irene Manders, Marlies A. van Houten, Jan Sinnige, Elisabeth A. M. Sanders, Jayant Kalpoe, Bjorn L. Herpers, Sem Aronson, Jeroen W. Den Boer, Ivar Lede, Steven F. L. van Lelyveld, Sophie Schuurmans Stekhoven, Fred Slijkerman Megelink |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Epidemiology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses law.invention COVID-19 Testing Antigen law Internal medicine medicine Distribution (pharmacology) Humans AcademicSubjects/MED00860 Child Polymerase chain reaction Retrospective Studies Transmission (medicine) business.industry SARS-CoV-2 Public health COVID-19 General Medicine Viral Load Cross-Sectional Studies age Original Article viral-load distribution business Viral load Cohort study |
| Zdroj: | International Journal of Epidemiology |
| Popis: | Background Describing the SARS-CoV-2 viral-load distribution in different patient groups and age categories. Methods All results from first nasopharyngeal (NP) and oropharyngeal (OP) swabs from unique patients tested via SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) collected between 1 January and 1 December 2020 predominantly in the Public Health Services regions Kennemerland and Hollands Noorden, province of North Holland, the Netherlands, were included in this study. SARS-CoV-2 PCR crossing-point (Cp)-values were used to estimate viral loads. Results In total, 278 455 unique patients were tested, of whom 9.1% (n = 25.374) were SARS-CoV-2-positive. PCRs performed by Public Health Services (n = 211 914), in which sampling and inclusion were uniform, revealed a clear relation between age and SARS-CoV-2 viral load, with especially children aged 79- and 30) was higher compared with other patients (31.1% vs 17.2%, p-value Conclusions In patients tested by Public Health Services, SARS-CoV-2 viral load increases with age. Further studies should elucidate whether the lower viral load in children is indeed related to their suggested limited role in SARS-CoV-2 transmission. Moreover, as rapid antigen tests are less sensitive than PCR, these results suggest that SARS-CoV-2 antigen tests have lower sensitivity in children than in adults. |
| Databáze: | OpenAIRE |
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