Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atheroscle-rosis in Watanabe Heritable Hyperlipidemic rabbits
| Autor: | V. Breinholt, Gitte Ravn-Haren, Birgit Fischer Hansen, Pia Knuthsen, Lars O. Dragsted, Henrik Lund Frandsen, Inge Lise F. Nielsen, Alicja Mortensen, Donald B. McPhail, Hai Ping Ma, Salka Elbøl Rasmussen, Riitta Freese |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Very low-density lipoprotein Erythrocytes Arteriosclerosis 030309 nutrition & dietetics Cholesterol VLDL Probucol Hyperlipidemias 030204 cardiovascular system & hematology Anthocyanins Beverages 03 medical and health sciences chemistry.chemical_compound Ribes 0302 clinical medicine Lipid oxidation medicine Animals Platelet activation Food science Aorta Triglycerides 2. Zero hunger Glutathione Peroxidase 0303 health sciences Superoxide Dismutase Cholesterol fungi food and beverages Platelet Activation Diet 3. Good health Lipoproteins LDL carbohydrates (lipids) chemistry Biochemistry Fruit Low-density lipoprotein Anthocyanin Female lipids (amino acids peptides and proteins) Rabbits Oxidation-Reduction Food Science Biotechnology medicine.drug Lipoprotein |
| Zdroj: | Molecular Nutrition & Food Research. 49:301-308 |
| ISSN: | 1613-4133 1613-4125 |
| DOI: | 10.1002/mnfr.200400097 |
| Popis: | Anthocyanin-rich beverages have shown beneficial effects on coronary heart disease in epidemiological and intervention studies. In the present study, we investigated the effect of black currant anthocyanins on atherosclerosis. Watanabe Heritable Hyperlipidemic rabbits (n = 61) were fed either a purified anthocyanin fraction from black currants, a black currant juice, probucol or control diet for 16 weeks. Purified anthocyanins significantly increased plasma cholesterol and low-density lipoprotein (LDL) cholesterol. Intake of black currant juice had no effect on total plasma cholesterol, but lowered very-low-density lipoprotein (VLDL) cholesterol significantly. There were no significant effects of either purified anthocyanins or black currant juice on aortic cholesterol or development of atherosclerosis after 16 weeks. Probucol had no effect on plasma cholesterol but significantly lowered VLDL-cholesterol and decreased aortic cholesterol accumulation. The erythrocyte antioxidant enzyme glutathione peroxidase was significantly increased by purified anthocyanins and superoxide dismutase was increased by both anthocyanin-containing treatments. Other markers of plasma antioxidant capacity, antioxidant enzymes, protein and lipid oxidation were not affected by any of the anthocyanin treatments. Adverse effects of purified anthocyanins were observed on plasma- and LDL-cholesterol. These effects were not observed with black currant juice, suggesting that black currants may contain components reducing the adverse effects of anthocyanins. |
| Databáze: | OpenAIRE |
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