Serum ferritin level is inversely related to number of previous pregnancy losses in women with recurrent pregnancy loss
| Autor: | Maja Georgsen, Maria Christine Krog, Andreas S. Rigas, Morten Bagge Hansen, Henriette Svarre Nielsen, Astrid Marie Kolte, Helene Westring Hvidman, Søren Ziebe, Anne-Sofie Korsholm, Anders Nyboe Andersen, Henrik Ullum |
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| Rok vydání: | 2020 |
| Předmět: |
Infertility
Adult medicine.medical_specialty Abortion Habitual Referral Adolescent media_common.quotation_subject Denmark Fertility Cohort Studies Young Adult Pregnancy medicine Humans Reproductive History media_common biology business.industry Obstetrics Previous pregnancy Obstetrics and Gynecology medicine.disease Ferritin Reproductive Medicine Ferritins biology.protein Female Live birth business Biomarkers Cohort study Follow-Up Studies |
| Zdroj: | Fertility and sterility. 115(2) |
| ISSN: | 1556-5653 |
| Popis: | To study whether low serum ferritin (s-ferritin) levels are associated with recurrent pregnancy loss (RPL), and whether low s-ferritin predicts the risk of another pregnancy loss or the ability to conceive.Cohort study.Fertility clinic at a university hospital.Eighty-four women referred to the RPL Unit and 153 women of reproductive age with no known fertility problem. s-Ferritin levels were measured in serum samples taken before pregnancy attempt.None.s-Ferritin levels were correlated to pregnancy history, ability to conceive, and time to conception during the first 2 years after sampling. Furthermore, s-ferritin levels were correlated to outcome of the first pregnancy after referral for RPL.Women with RPL had lower s-ferritin than the comparison group, 39.9 μg/L versus 62.2 μg/L, and had a higher prevalence of low iron stores (s-ferritin30 μg/L), 35.7% versus 13.7%. We found an inverse relationship between s-ferritin level and number of pregnancy losses before referral. We did not find s-ferritin level to be associated with ability to conceive or time to pregnancy in either group. Nor did s-ferritin level predict the risk of losing the first pregnancy after referral for RPL.The inverse relationship between s-ferritin levels and previous pregnancy losses suggests that low s-ferritin is associated with a more severe reproductive disturbance in women with RPL. Whether low s-ferritin is causally related to RPL and if such women could benefit from iron supplementation to achieve a live birth warrants further investigation. |
| Databáze: | OpenAIRE |
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