In Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography

Autor: Pasi Virta, Tiina Laitala-Leinonen, Meeri Käkelä, Harri Lönnberg, Anne Roivainen, Matthieu Bourgery, Riikka Siitonen, Heidi Liljenbäck, Päivi Poijärvi-Virta, Jussi Mäkilä, Satish Jadhav, Kiira Rimpilä
Rok vydání: 2016
Předmět:
Zdroj: Molecular Pharmaceutics. 13:2588-2595
ISSN: 1543-8392
1543-8384
DOI: 10.1021/acs.molpharmaceut.6b00261
Popis: A bis(phosphonate) conjugate of 2'-O-methyl oligoribonucleotide (microRNA-21) was synthesized and used as a bone-targeting carrier in the systemic delivery of a (68)Ga-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-chelated 2'-O-methyl oligoribonucleotide (anti-microRNA-21). The whole-body biodistribution of the double helical RNA was monitored by positron emission tomography (PET), which verified the expected bis(phosphonate)-induced bone accumulation in healthy rats.
Databáze: OpenAIRE