Prevalence of CD8+ T-cell expansions in relation to age in healthy individuals
| Autor: | Cheri Roberton, Brian L. Kotzin, Marian Rewers, Jill M. Norris, Richard F. Hamman, Nancy S. Ricalton |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Aging Receptors Antigen T-Cell alpha-beta Biology CD8-Positive T-Lymphocytes Antigen Reference Values T-Lymphocyte Subsets Cytotoxic T cell Humans Lymphocyte Count Child Aged Demography Aged 80 and over Sex Characteristics Healthy population Bacterial Infections Middle Aged Peripheral blood CD4 Lymphocyte Count Vaccination Socioeconomic Factors Virus Diseases Healthy individuals Child Preschool Immunology Etiology Female Geriatrics and Gerontology CD8 |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences. 53(3) |
| ISSN: | 1079-5006 |
| Popis: | Clonal CD8* T-cell expansions have been identified in the peripheral blood of healthy adults and occasionally in children. These expansions are often large, yet their etiology is unknown. This study evaluated the relationship between age and the prevalence of these expansions in a healthy population (n = 147) aged 9 months to 85 years. Expansions were determined using immunofluorescence staining with monoclonal antibodies to different T-cell receptor (TCR)-variable regions. The overall prevalence was 13.6% and increased linearly with age as follows: 0% for 9-month-olds, 2.7% for 4- to 12-year-olds, 13.3% for 20- to 30-year-olds, 20.7% for 35- to 50-year-olds, and 33.4% for 65- to 85-year-olds. Multiple expansions were observed only in the oldest group. Certain TCR-variable regions appeared to be preferentially utilized by these expansions, which suggests a response to a particular antigenic stimulus. Childhood illness and vaccination histories did not provide insight into the etiology of these expansions. Age was the only measured factor that was associated with these expansions. |
| Databáze: | OpenAIRE |
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