Visfatin Levels in Subclinical Hypothyroidism
| Autor: | Melek Tunc Ata, Can Ozlu, Guzin Fidan Yaylali, Fulya Akin, Mehmet Tural, Kamil Isler, Sebahat Turgut, Seyma Ozkan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
enzyme assay endocrine system diseases medicine.medical_treatment Visfatin blood level Biochemistry Analytical Chemistry thyrotropin chemistry.chemical_compound 0302 clinical medicine molecular pathology middle aged Drug Discovery Subclinical hypothyroidism Adipokine Subclinical infection clinical article thyroid function test medicine.diagnostic_test adult enzyme activity subclinical hypothyroidism nicotinamide phosphoribosyltransferase Molecular Medicine Thyroid function medicine.symptom hormones hormone substitutes and hormone antagonists insulin endocrine system medicine.medical_specialty 030209 endocrinology & metabolism Bioengineering Inflammation Thyroid function tests Article 03 medical and health sciences Internal medicine medicine controlled study human free thyroxine index outcome assessment thyroxine Triglyceride business.industry Cholesterol Insulin disease association free liothyronine index 030104 developmental biology Endocrinology chemistry liothyronine business disease activity |
| Zdroj: | International Journal of Peptide Research and Therapeutics. 22:11-14 |
| ISSN: | 1573-3904 1573-3149 |
| Popis: | Alterations in thyroid function are associated with changes in body weight, metabolism, and low-grade inflammation abnormal thyroid function may be associated with disturbances in the production of adipokines also. Although there have been studies showing changes in visfatin levels in thyroid dysfunction, exact relationship between them was still unclear. Our aim was to evaluate serum concentrations of visfatin in patients with subclinical thyroid dysfunction before and after normalization of thyroid function tests. The study included 43 patients (mean age 50.1 ± 10.6 years) with subclinical hypothyroidism. Serum insulin, visfatin, TSH, free T4 (FT4) and free T3 (FT3) levels of subjects were analyzed. Visfatin levels were measured in all patients before starting therapy and after normalization of thyroid function. Serum visfatin levels of subclinical hypothyroid patients were 0.99 ± 0.45 and they were similar after normalization of thyroid function (p = 0.394). Serum visfatin levels were negatively correlated with FT4 levels before treatment (r = -0.329 p < 0.05). There was no significant correlation between serum levels of visfatin and the serum levels of TSH and FT3. Serum visfatin levels did not correlate with insulin, fasting blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride levels. In this study, it was shown visfatin levels did not change after replacement therapy in patients with subclinical hypothyroidism. Subclinical hypothyroid state may be an earlier stage regarding the changes of adipocytokines specifically the visfatin secretion as seen in overt hypothyroidism. © 2015 Springer Science+Business Media New York. |
| Databáze: | OpenAIRE |
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