Effect of vitamin E supplementation on circulating cell adhesion molecules pre- and post-coronary angioplasty
| Autor: | JC Williams, Samantha Tull, G. Ferns, P. K. Verma, Anthony H. Gershlick, B Starkey, LA Forster |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant P-selectin Endothelium medicine.medical_treatment Clinical Biochemistry Coronary Disease Enzyme-Linked Immunosorbent Assay Placebo Endothelial activation Internal medicine Angioplasty medicine Humans Vitamin E Platelet Angioplasty Balloon Coronary Aged Aged 80 and over business.industry General Medicine Middle Aged Intercellular Adhesion Molecule-1 Platelet Activation P-Selectin Endocrinology medicine.anatomical_structure Immunology Dietary Supplements Female Endothelium Vascular business |
| Zdroj: | Annals of clinical biochemistry. 37 |
| ISSN: | 0004-5632 |
| Popis: | The soluble adhesion molecules P-selectin (sP-selectin) and intercellular adhesion molecule-1 (sICAM-1) are derived from platelets and endothelial cells. Circulating concentrations of these soluble adhesion molecules are raised in patients with atherosclerosis and following percutaneous transluminal coronary angioplasty (PTCA). We have investigated the effects of vitamin E supplements (800 IU/day) on circulating plasma ICAM-1 and P-selectin levels pre- and post-PTCA. Patients, randomized to group, were pre-treated with vitamin E or placebo (soybean oil) for 1 month before routine PTCA. Plasma sICAM-1 and sP-selectin were measured by enzyme-linked immunosorbent assay on blood taken immediately pre- and post-PTCA. Total protein and α-tocopherol were measured on the same samples. Plasma α-tocopherol concentrations increased in patients receiving vitamin E: 19·1 (1·5) [mean (standard error of the mean, SEM)] mg/mL post-PTCA versus 13·9 (0·6) mg/mL pre-PTCA ( n=23; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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