Human polyomavirus KI, WU, BK, and JC in healthy volunteers
| Autor: | Giselle P. A. Pena, Gabriella da Silva Mendes, Helver G. Dias, Lucas S. Gavazzoni, Ariane Ribeiro Amorim, Norma Santos |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Saliva Adolescent 030106 microbiology Biology Asymptomatic Polymerase Chain Reaction law.invention Excretion 03 medical and health sciences Young Adult 0302 clinical medicine Medical microbiology law Healthy volunteers Epidemiology medicine Humans 030212 general & internal medicine Child Asymptomatic Infections Polymerase chain reaction Aged Polyomavirus Infections Transmission (medicine) Infant General Medicine Middle Aged Virology Infectious Diseases Cross-Sectional Studies Child Preschool Female medicine.symptom Polyomavirus Brazil |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 38(1) |
| ISSN: | 1435-4373 |
| Popis: | Despite the growing importance of infections caused by the human polyomaviruses (HPyVs), information about their transmission, pathogenesis, and epidemiology is scarce. The objective of this work was to evaluate the excretion and distribution of HPyV (HPyV1-HPyV4 [former BKPyV, JCPyV, KIPyV, and WUPyV, respectively]) among asymptomatic individuals from different geographic regions in Brazil, in order to verify the existence of distinct epidemiologic patterns among the Brazilian population. Saliva samples from 889 healthy volunteers living in nine locations in Brazil were analyzed by real-time polymerase chain reaction (PCR) to detect HPyV1–4. Among 889 participants, 346 (39%) had evidence of infection with one or more HPyV species: 127 (14.3%) had HPyV1 only; 70 (7.9%) had HPyV3 only; 60 (6.7%) had HPyV4 only, and 25 (2.8%) had HPyV2 only. Coinfections were detected in 64 participants (7.3%). Although HPyV excretion was detected in samples from all locations, the frequency and distribution of viral species varied significantly. The epidemiologic findings presented demonstrate that the four HPyV species studied are circulating in five geographic regions of Brazil. Salivary excretion of these viruses appears common among healthy Brazilians. The distribution of viral species varies considerably between regions as well as within regions. |
| Databáze: | OpenAIRE |
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