Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion
| Autor: | Adem Küçük, Naci Topaloğlu, Şule Yıldırım, Mustafa Tekin, Ahmet Yildirim, Havva Erdem, Dilek Ulker Cakir, Mesut Erbaş |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty endocrine system diseases Ischemia-modified albumin Ovary 03 medical and health sciences 0302 clinical medicine otorhinolaryngologic diseases medicine 030219 obstetrics & reproductive medicine business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid Ovarian torsion 030208 emergency & critical care medicine Diagnostic marker lcsh:RC86-88.9 medicine.disease Rats body regions surgical procedures operative medicine.anatomical_structure biological sciences Original Article business |
| Zdroj: | Turkish Journal of Emergency Medicine Turkish Journal of Emergency Medicine, Vol 16, Iss 1, Pp 8-11 (2016) |
| ISSN: | 2452-2473 |
| DOI: | 10.1016/j.tjem.2016.02.004 |
| Popis: | Yildirim, Sule/0000-0002-1815-808X WOS: 000393518500002 PubMed: 27239631 Objectives: Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion. Material and methods: Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples. Results: The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlationwas found between IMA levels and histopathologic changes (Spearman's rho = vertical bar 0.987, p < 0.001). Conclusion: Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. |
| Databáze: | OpenAIRE |
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