Changes in plasma C1q, apelin and adropin concentrations in older adults after descending and ascending stair walking intervention
Autor: | Mei Yen Chen, Hsin Lian Chen, Chung Chan Hsieh, Wei Chin Tseng, Yuh Chuan Huang, Kuo-Wei Tseng, Tsang Hai Huang, Kazunori Nosaka, Tai Ying Chou, Trevor C. Chen |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Physiology Science Physical fitness Stair walking Blood lipids Blood Pressure Isometric exercise Walking Article Internal medicine Isometric Contraction medicine Humans Insulin Obesity Aged Aged 80 and over Multidisciplinary Knee extensors business.industry Complement C1q Insulin sensitivity Glucose Tolerance Test Middle Aged Lipids Apelin Ageing Blood pressure Cholesterol Physical Fitness Cardiology Medicine Intercellular Signaling Peptides and Proteins Female business |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
ISSN: | 2045-2322 |
Popis: | This study compared changes in plasma complement component 1q (C1q), apelin and adropin concentrations in older obese women after descending (DSW) and ascending stair walking (ASW) training (n = 15/group) performed twice a week for 12 weeks, with gradual increases in exercise time from 5 to 60 min. Fasting blood samples were collected 3 days before the first and 4 days after the last training session. The improvements in the maximal voluntary isometric contraction (MVIC) strength of the knee extensors, functional physical fitness [e.g., 30-s chair stand (CS) performance], resting systolic blood pressure (SBP), insulin sensitivity [e.g., oral glucose tolerance test (OGTT)] and blood lipid profiles [e.g., total cholesterol (TC)] were greater (p < 0.05) in the DSW than ASW group. Plasma C1q decreased (− 51 ± 30%), and apelin (23 ± 15%) and adropin (127 ± 106%) increased (p ≤ .0.05) only after DSW. Significant (p ≤ 0.01) partial correlations were found between the pre- to post-DSW changes in C1q, apelin or adropin and changes in outcome measures [e.g., C1q and MVIC (r = − 0.837), apelin and SBP (r = − 0.854), and andropin and OGTT (r = − 0.729)]. These results showed that greater decreases in plasma C1q and greater increases in apelin and adropin concentrations were associated with greater improvements in outcome measures after DSW than after ASW. |
Databáze: | OpenAIRE |
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