Supplementary Figure 4 from Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells

Autor: Antoni Ribas, Siwen Hu-Lieskovan, Begoña Comin-Anduix, Thomas G. Graeber, Ashani T. Weeraratna, Marcus Bosenberg, Abibatou Ndoye, Katrina Meeth, Lidia Robert, Giulia Parisi, Jennifer Tsoi, Angel Garcia-Diaz, Jesse M. Zaretsky, Blanca Homet Moreno
Rok vydání: 2023
DOI: 10.1158/2326-6066.22538131.v1
Popis: Gating strategy of CD11c+B220-, CD11c+B220+, CD11c+B220-CD8+ and CD11c+B220-CD103+ cells; gating strategy of CD11b+MHC-IIhigh DCs in CD11c+ cells; gating strategy of CD11b+F4/80+TAMs, CD11b+F4/80+MHC-IIlow TAMs and CD11b+F4/80+MHC-IIhigh TAMs; gating strategy of MO-MDSC (CD11b+Ly6ChighLy6Glow) and PMN-MDSC (CD11b+Ly6ClowLy6Ghigh); gating strategy of Tregs (CD4+CD25+FoxP3+); corresponding normalized enrichment scores (NES), P values and false discovery rates (FDR) of the GSEA plots for YUMM2.1 versus YUMM1.1 enriched pathways involved in immune response, cytokine production and inflammatory response.
Databáze: OpenAIRE