Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery

Autor:	Karam Kim, Po Soon Kang, Seung Hyun Lee, Nam Sik Woo, Woon Seok Kang, Jun Seok Kim, Seong-Hyop Kim, Hang Rae Kim, Chung-Sik Oh
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Adult CD4-Positive T-Lymphocytes Male medicine.medical_specialty Tetraspanins medicine.medical_treatment Science Hemodynamics 030204 cardiovascular system & hematology Article Sevoflurane law.invention 03 medical and health sciences 0302 clinical medicine Antigens Neoplasm 030202 anesthesiology law medicine Cardiopulmonary bypass Humans Weaning Prospective Studies Cardiac Surgical Procedures Propofol Aged Cardiopulmonary Bypass Multidisciplinary Cluster of differentiation business.industry Apyrase Perioperative Middle Aged Surgery Cytokine Gene Expression Regulation Anesthesia Anesthetics Inhalation Cytokines Medicine Female business Anesthetics Intravenous medicine.drug
Zdroj:	Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports
ISSN:	2045-2322
Popis:	High expression of cluster of differentiation (CD)39 and CD73 has cardio-protective effects. We hypothesised that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing open heart surgery (OHS). The objective of this prospective randomized trial was to compare the changes in CD39 and CD73 levels in CD4+ T cells between propofol- and sevoflurane-based anaesthesia during OHS. The study randomly allocated 156 patients undergoing OHS to a propofol or sevoflurane group. Blood was obtained preoperatively and up to 48 hours after weaning from cardiopulmonary bypass (CPB). The expression levels of CD39 and CD73 in circulating CD4+ T cells, serum cytokines and other laboratory parameters were analysed. The primary outcome was the expression of CD39 and CD73 on CD4+ T cells. Demographic data and perioperative haemodynamic changes did not show significant differences between the two groups. The expression of CD39 and CD73 in the sevoflurane group was significantly lower than in the propofol group (P + T cells compared to sevoflurane-based anaesthesia during OHS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b48219a713416966c8fb581f467e1a https://doaj.org/article/51f50a48e9894dcc84e7ccf9a4804095 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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