Polycystic ovary syndrome
| Autor: | Joop S.E. Laven, Kevin D. Sinclair, Rosalieke E. Wiegel, Pauline W. Jansen, Régine P.M. Steegers-Theunissen |
|---|---|
| Přispěvatelé: | Obstetrics & Gynecology, Child and Adolescent Psychiatry / Psychology, Clinical Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system diseases Hypothalamic–pituitary–gonadal axis Review Bioinformatics lcsh:Chemistry 0302 clinical medicine prevention Risk Factors PCOS Medicine Overeating Age of Onset Child lcsh:QH301-705.5 Spectroscopy Brain Diseases emotional disturbance DNA methylation General Medicine Polycystic ovary Computer Science Applications Eating disorders nutrition Female medicine.symptom Dieting Polycystic Ovary Syndrome Adolescent Psychology Adolescent 030209 endocrinology & metabolism eating disorders Catalysis Inorganic Chemistry Feeding and Eating Disorders 03 medical and health sciences SDG 3 - Good Health and Well-being Endocrine system Humans Physical and Theoretical Chemistry Molecular Biology psychological stress business.industry Organic Chemistry Puberty neuroendocrine hormones medicine.disease Obesity 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Adolescent Behavior business Hormone |
| Zdroj: | International Journal of Molecular Sciences, 21(21):8211, 1-20. Multidisciplinary Digital Publishing Institute (MDPI) International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 8211, p 8211 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Polycystic ovary syndrome (PCOS) is an endocrine condition associated with reproductive and psychiatric disorders, and with obesity. Eating disorders, such as bulimia and recurrent dieting, are also linked to PCOS. They can lead to the epigenetic dysregulation of the hypothalamic–pituitary–gonadal (HPG) axis, thereby impacting on ovarian folliculogenesis. We postulate that PCOS is induced by psychological distress and episodes of overeating and/or dieting during puberty and adolescence, when body dissatisfaction and emotional distress are often present. We propose that upregulated activation of the central HPG axis during this period can be epigenetically altered by psychological stressors and by bulimia/recurrent dieting, which are common during adolescence and which can lead to PCOS. This hypothesis is based on events that occur during a largely neglected stage of female reproductive development. To date, most research into the origins of PCOS has focused on the prenatal induction of this disorder, particularly in utero androgenization and the role of anti-Müllerian hormone. Establishing causality in our peripubertal model requires prospective cohort studies from infancy. Mechanistic studies should consider the role of the gut microbiota in addition to the epigenetic regulation of (neuro) hormones. Finally, clinicians should consider the importance of underlying chronic psychological distress and eating disorders in PCOS. |
| Databáze: | OpenAIRE |
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