Effectiveness of influenza vaccination during pregnancy to prevent severe infection in children under 6 months of age, Spain, 2017–2019
| Autor: | Xabier Beraza Ortiz, Isabel Falcón García, Amparo Larrauri, Carmen Quiñones, Luis García Comas, María Isabel Barranco Boada, Francisco Pozo, Domingo Ángel Núñez Gallo, Carmen Muñoz Almagro, Francisco Javier Roig Sena, Clara Mazagatos, Pere Godoy, Núria Torner Gràcia, Miriam García, Concepción Delgado-Sanz, Larraitz Etxebarriarteun Aranzabal, Jesús Castilla Catalán, Pilar Gallego Berciano, Alin Gherasim, Gonzalo Gutiérrez, Eva Martínez Ochoa, Katja Villatoro Bongiorno, Jesús Oliva, Daniel Castrillejo Pérez, Jaume Giménez Duran, V. García, Ana Rivas, Begoña López Hernández, Luis Javier Viloria Raymundo, Ismael Huerta González |
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| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Influenza vaccine 030231 tropical medicine Population Maternal vaccination Pilot Projects 03 medical and health sciences 0302 clinical medicine Pregnancy Influenza Human medicine Screening method Humans 030212 general & internal medicine Pregnancy Complications Infectious Child education Disease burden Retrospective Studies education.field_of_study General Veterinary General Immunology and Microbiology business.industry Vaccination Public Health Environmental and Occupational Health Infant virus diseases medicine.disease Influenza Infectious Diseases Influenza Vaccines Spain Vaccination coverage Screening Molecular Medicine Female business Vaccine |
| Zdroj: | Vaccine. 38:8405-8410 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2020.07.014 |
| Popis: | Introduction Influenza vaccination is recommended to pregnant women in Spain to reduce the risk of influenza-related complications. Influenza related hospitalizations pose a significant disease burden in children every year. Although children below 6 months are too young to be vaccinated, they can receive protection against influenza through vaccination of their mothers during pregnancy. We estimated the effectiveness of maternal influenza vaccination to prevent influenza hospitalizations in infants under 6 months of age. Methods This is a retrospective pilot study, using data from the Severe Hospitalized Confirmed Influenza Cases (SHCIC) surveillance system in seasons 2017/18 and 2018/19 in Spain. Maternal vaccination status during pregnancy was collected for cases in children 6 months and younger hospitalized with confirmed influenza infection. Influenza vaccine effectiveness was estimated using the screening method, by comparing the proportion of children with vaccinated mothers during pregnancy (proportion of cases vaccinated, PCV), with the vaccination coverage among pregnant women in Spain (proportion of population vaccinated, PPV). Results For all the study period, the PCV was 17% and the PPV was 35%. Influenza vaccination in mothers during pregnancy prevented influenza confirmed hospitalizations in infants aged 6 months and younger with a 61% (95%CI: 27–79%) effectiveness. Conclusions In line with evidence from other countries, influenza vaccination during pregnancy protects infants up to 6 months of age from influenza hospitalizations in Spain. These results support current recommendations of influenza vaccination in pregnant women, and more studies are needed in Spain to confirm the double protection of maternal vaccination in mothers and infants. |
| Databáze: | OpenAIRE |
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