Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial

Autor:	Lauren F. McLellan, Jennifer L. Hudson, Viviana M. Wuthrich, Valsamma Eapen, Ronald M. Rapee, Heidi J. Lyneham
Rok vydání:	2021
Předmět:	Sertraline business.industry Cognition medicine.disease Placebo law.invention Double blind Psychiatry and Mental health Randomized controlled trial law Pill Medicine Anxiety medicine.symptom business Applied Psychology Anxiety disorder Clinical psychology medicine.drug
Zdroj:	Psychological Medicine. 53:1741-1749
ISSN:	1469-8978 0033-2917
Popis:	BackgroundAnxiety disorders are the most prevalent mental disorder in children and young people. Developing effective therapy for these children is critical to reduce mental disorders across the lifespan. The study aimed to evaluate the efficacy of combining cognitive behavioural therapy (CBT) and sertraline (SERT) in the treatment of anxiety in youth, using a double-blind randomised control trial design.MethodsNinety-nine youth (ages 7–15 years) with an anxiety disorder were randomly allocated to either individual (CBT) and SERT or individual CBT and pill placebo and assessed again immediately and 6 months after treatment.ResultsThere were no significant differences between conditions in remission of primary anxiety disorder or all anxiety disorders. Furthermore, there were no significant differences in rates of change in diagnostic severity, parent-reported anxiety symptoms, child-reported anxiety symptoms or life interference due to anxiety.ConclusionsThe efficacy of CBT for children and adolescents with anxiety disorders is not significantly enhanced by combination with a short-term course of anti-depressants over and above the combined effects of pill placebo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b41a94e76adfeda46061790e3282a9 https://doi.org/10.1017/s0033291721003329 Zobrazit plný text záznamu