Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze
| Autor: | R.F. Ritzmann, C.L. Melchior |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Neuroactive steroid medicine.drug_class medicine.medical_treatment Clinical Biochemistry Pharmacology Anxiety Motor Activity Toxicology Biochemistry Anxiolytic Behavioral Neuroscience chemistry.chemical_compound Mice Internal medicine medicine Animals Biological Psychiatry gamma-Aminobutyric Acid Ethanol Behavior Animal Dose-Response Relationship Drug Sulfates Mice Inbred C57BL Steroid hormone Dose–response relationship Endocrinology chemistry Anxiogenic Pregnenolone Pregnenolone sulfate Stress Psychological medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 48(4) |
| ISSN: | 0091-3057 |
| Popis: | The neurosteroids pregnenolone and pregnenolone sulfate were tested for anxiogenic/anxiolytic effects in mice on the elevated plus-maze. Pregnenolone in a dose of 0.01 micrograms/kg increased motor activity and caused an anxiogenic response, i.e., a decreased number of entries onto the open arms of the plus-maze. Pregnenolone sulfate had no effect on motor activity in the doses tested but showed a biphasic response on the plus-maze: at 10.0 and 1.0 micrograms/kg pregnenolone sulfate caused an anxiogenic response but at 0.1 microgram/kg it produced an anxiolytic response. When administered with 1.5 g/kg ethanol, neither neurosteroid altered the depression in motor activity caused by ethanol. However, all doses of pregnenolone tested blocked the anxiolytic effect of ethanol on the plus-maze while one dose of pregnenolone sulfate, 1.0 microgram/kg, attenuated the response to ethanol. These results support the suggestion that these neurosteroids could play a role in the initial response to stress and indicate that further work needs to be done to determine the mechanism for the interaction with ethanol. |
| Databáze: | OpenAIRE |
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