Chronic cannabinoid administration to periadolescent rats modulates the metabolic response to acute cocaine in the adult brain
| Autor: | Emilio Ambrosio, Javier Pascau, Miguel Miguéns, Verónica García-Vázquez, Carmen García-Lecumberri, Nuria Del Olmo, Alejandro Higuera-Matas, Gonzalo L. Montoya, María Luisa Soto-Montenegro, Juan José Vaquero, Manuel Desco |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Aging medicine.medical_treatment Dorsal striatum Cocaine Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Rats Wistar Biología y Biomedicina Septal nuclei business.industry Cannabinoids Brain Magnetic Resonance Imaging Rats Neostriatum PET Endocrinology medicine.anatomical_structure Oncology Female Septal Nuclei Cannabinoid business |
| Zdroj: | e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid instname |
| ISSN: | 1860-2002 2004-0814 |
| Popis: | Purpose: To analyze brain metabolic response to acute cocaine in male and female Wistar rats with or without a history of cannabinoid exposure during periadolescence. Procedures: The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were administered to male and female rats during periadolescence. When these animals reached adulthood, saline and cocaine-induced changes in 2-deoxy-2-[18F]fluoro D glucose (FDG) uptake were studied by positron emission tomography. Results: The baseline (post-saline) metabolism in the septal nuclei was higher in CP-females than in VH-females, although septal metabolism was lower in CP-females after cocaine, reaching similar values to those of VH-females at baseline. Cocaine did not affect metabolism in VH-females. Periadolescent cannabinoid treatment did not influence baseline metabolism in males although cocaine reduced the FDG uptake in the dorsal striatum of males that received the VH but not CP. Conclusions: These results suggest that cannabinoids during periadolescence modify baseline and cocaine-evoked brain metabolism in a sex-dependent manner. In the case of CP-females, the involvement of septal metabolic alterations in their susceptibility to the rewarding effects of cocaine should be further investigated. This work was supported by grants from the Ministerio de Educación y Ciencia (Grants nº SAF2004-08148 and SAF2007-064890); Ministerio de Sanidad y Consumo (Grants RD06/ 00170029 of Instituto de Salud Carlos III, PNSD 2004 2007 and 2008 2010); Dirección General de Investigación de la Comunidad de Madrid (Grant S-SAL/0261/2006, I+D CANNAB-CM Consortium); and UNED (Plan de Promoción de la Investigación) to EA, and grants from the “Ministerio de Ciencia y Tecnología” (TEC2004-07052-C02-01/TCM), “Ministerio de Sanidad y Consumo” (CIBER CB06/01/0079, PNSD 2007 2010, FIS CP08/00017), “Ministerio de Industria” (CENIT program) and “Fundación de Investigación Médica Mutua Madrileña” (2007 2010 and 2008 2011) to MD. Publicado |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink