Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study

Autor: Chao Li, Tianyue Wang, Kanghui Yu, Kelei Hua, Guihua Jiang, Qiying Ke, Xiaofen Ma, Shishun Fu, Yunfan Wu, Changhong Li, Zhigang Bai, Mengchen Liu, Junzhang Tian, Yi Yin
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Rest
Cognitive Neuroscience
Poison control
Right angular gyrus
Audiology
lcsh:Computer applications to medicine. Medical informatics
behavioral disciplines and activities
lcsh:RC346-429
050105 experimental psychology
Stress Disorders
Post-Traumatic
Angular gyrus
Young Adult
03 medical and health sciences
0302 clinical medicine
Parietal Lobe
mental disorders
Injury prevention
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Brain Mapping
medicine.diagnostic_test
Resting state fMRI
Traffic accidents
business.industry
Traffic accident
fMRI
05 social sciences
Accidents
Traffic
Traumatic stress
Regular Article
PTSD
Middle Aged
Magnetic Resonance Imaging
Neurology
lcsh:R858-859.7
Female
Neurology (clinical)
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 24, Iss, Pp-(2019)
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2019.101951
Popis: Objectives The present study explored the changes in spontaneous regional activity in post-traumatic stress disorder (PTSD) patients, who experienced severe traffic accidents. Methods 20 drug-naive PTSD patients and 18 healthy control subjects were imaged using resting-state functional magnetic resonance imaging (rs-fMRI) and analyzed by the algorithm of regional homogeneity (ReHo). Results Compared to the healthy control group, the PTSD group showed decreased ReHo values in the right angular gyrus. In addition, a negative correlation was found between the activity level of the angular gyrus and the CAPS score. Conclusion The dysfunctions were found in the memory- and emotion-related areas, suggested a possible mechanism of memory dysregulation that might be related to the intrusive memory symptoms of PTSD. These results provided imaging evidence that might provide an in-depth understanding of the intrinsic functional architecture of PTSD.
Highlights • This research focus on the PTSD patients without comorbidities, so that the confounding factors could be avoided. • This research using regional homogeneity measured the temporal synchronization of the intrinsic spontaneous brain activity of the voxels. ReHo is a reliable and efficient index that has been successfully applied in many conditions. • This study explored the changes in spontaneous regional activity in post-traumatic stress disorder patients, who experienced severe traffic accidents. • Compared to the normal control group, the PTSD group showed lower ReHo values in the right angular. These results provided imaging evidence that might provide an in-depth understanding of the intrinsic functional architecture of PTSD.
Databáze: OpenAIRE
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