Association of DQB1*0302 Alloantigens in Japanese Pediatric Patients with Steroid-Sensitive Nephrotic Syndrome
| Autor: | Kasumi Kuramitsu Abe, Toshiki Hiratsuka, Keiko Tokieda, Kikuo Arakawa, Setsuya Naito, Noboru Tsuru, Isao Michinaga, Satoru Ogahara |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Nephrotic Syndrome
Adolescent endocrine system diseases medicine.drug_class medicine.medical_treatment Molecular Sequence Data Mongoloid Human leukocyte antigen HLA-DQ alpha-Chains Japan HLA-DQ Antigens medicine HLA-DQ beta-Chains Humans Typing Allele Child Alleles Chemotherapy Base Sequence business.industry Glomerulonephritis DNA medicine.disease Immunology Corticosteroid Steroids business Nephrotic syndrome |
| Zdroj: | Nephron. 70:28-34 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | We identified human leukocyte alloantigens (HLA) class II alleles in 24 Japanese children with steroid-sensitive nephrotic syndrome (SSNS) by deoxyribonucleic acid (DNA) typing. The DQA1 and DQB1 alleles were identified using sequence-specific oligonucleotide probes for DQA and DQB. The frequency of DQB1*0302 was significantly higher in the patients than in the controls (54.0 vs. 16.0%, respectively; relative risk, RR = 6.2; pc0.00009. We also found that the frequency of DQA1*0103 in the patients was significantly lower than in the controls (RR = 0.194, pc0.04). Several studies have identified an association between certain HLA by serotyping. In the present study, we investigated the HLAs of Japanese patients with SSNS by DNA typing and observed a significant increase in the frequency of DQB1*0302 in patients with the disease. HLA-DQ3, which was proven to be associated with SSNS, consists of HLA DQ7, 8 and 9. DQB1*0302 is a component of HLA-DQ8. So we proposed the increase of DQ3 was due to an increase in DQ8. |
| Databáze: | OpenAIRE |
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