Micro-HPLC–UV analysis of cocaine and its adulterants in illicit cocaine samples seized by Austrian police from 2012 to 2017
| Autor: | Nives Galić, Martin G. Schmid, Kristinka Vinković |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chromatography
Lidocaine Chemistry 010401 analytical chemistry Clinical Biochemistry Pharmaceutical Science Levamisole 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 03 medical and health sciences Benzocaine Procaine 0302 clinical medicine Phenacetin Cocaine adulterants micro-HPLC UV detection caffeine procaine levamisole phenacetin lidocaine benzocaine medicine 030216 legal & forensic medicine Uv detection Micro hplc medicine.drug |
| Zdroj: | Journal of Liquid Chromatography & Related Technologies. 41:6-13 |
| ISSN: | 1520-572X 1082-6076 |
| DOI: | 10.1080/10826076.2017.1409237 |
| Popis: | The worldwide consumption of illicit drugs presents a big problem in terms of health care and prosecution. In the recent years, hundreds of novel psychoactive substances came up and were traded via the Internet, but there is still a big demand for classic illicit drugs such as cocaine, heroin, cannabis and ecstasy. Among these, cocaine particularly is frequently altered not only with excipients, but also with other physiologically active substances. The purpose of this work was to estimate the trend of cocaine purity and abundance of its adulterants in samples seized by Austrian police from 2012 to 2017. A micro-HPLC method for quantification of cocaine and its most common adulterants was developed and validated using gradient elution and UV detection at four wavelengths. 110 cocaine samples were analysed. In all the samples cocaine was present as hydrochloric salt. Caffeine, procaine, levamisole, phenacetin, lidocaine and benzocaine were the most abundant adulterants. |
| Databáze: | OpenAIRE |
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