Efficacy and safety of statin and fibrate combination therapy in lipid management
| Autor: | Epari Sanjeeva Rao, Lalit Kumar Meher, Kirtikumar D Modi, Sruti Jammula, Sunil Kumar Kota |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Statin Combination therapy medicine.drug_class Endocrinology Diabetes and Metabolism Hyperlipidemias Fibrate Risk Assessment Fenofibrate Muscular Diseases Refractory Diabetes mellitus Internal medicine Hyperlipidemia Atorvastatin Internal Medicine medicine Humans Pyrroles cardiovascular diseases Myopathy Hypolipidemic Agents business.industry Anticholesteremic Agents Incidence (epidemiology) nutritional and metabolic diseases General Medicine medicine.disease Treatment Outcome Endocrinology Heptanoic Acids Drug Therapy Combination Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom business |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 6:173-174 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2012.09.009 |
| Popis: | Adequate control of hyperlipidemia is of paramount importance for prevention of vascular events. Statins and fibrates are well established treatments for hyperlipidemia. Combination therapy with a statin and fibrate offers significant therapeutic advantage for the treatment of severe or refractory mixed hyperlipidemia. Although such a combination does increase the risk of myopathy, with an incidence of approximately 0.12%, this small risk of myopathy rarely outweighs the established morbidity and mortality benefits of achieving lipid goals. Nevertheless, a higher incidence of myopathy has been reported with statin monotherapy. Statin + fibrate therapy should be considered if monotherapy or adding other drugs (e.g. cholesterol absorption inhibitors, omega-3 fatty acids or nicotinic acid) did not achieve lipid targets or is impractical. The current article focuses on recent studies highlighting the beneficial effects of this combination. |
| Databáze: | OpenAIRE |
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