Use of Conjoint Analysis to Assess Breast Cancer Patient Preferences for Chemotherapy Side Effects
| Autor: | Mark Clemons, Sasha Mazzarello, Susan Dent, Iryna Kuchuk, Nathaniel Bouganim, Jessica Grinspan, Kathleen Beusterien, Lisa Vandermeer, Stan Z. Gertler |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Cross-sectional study medicine.medical_treatment Breast Neoplasms Breast cancer Internal medicine Breast Cancer Antineoplastic Combined Chemotherapy Protocols Medicine Humans Chemotherapy Internet business.industry Data Collection Intravenous chemotherapy Patient Preference Middle Aged Treatment side effects medicine.disease Patient preference Surgery Conjoint analysis Cross-Sectional Studies Female Neoplasm Grading business |
| Popis: | Objective. Our objective was to evaluate preferences associated with grade I/II and grade III/IV chemotherapy side effects among breast cancer patients receiving chemotherapy. We also assessed trade-offs that patients are willing to make between treatment side effects and the route and schedule of treatment administration. Methods. In this cross-sectional study, patients receiving chemotherapy for breast cancer completed a one-time Web survey. Conjoint analysis was used to elicit preferences for 17 grade I/II and III/IV side effects associated with available chemotherapies and regimens. In the analysis, the risk of each side effect was increased by 5%, holding all others constant, and the respective impact on patient preferences was identified. Results. A total of 102 women participated (mean age 54 ± 11). Among the grade I/II side effects, a 5% reduction in the risk of sensory neuropathy, nausea, and motor neuropathy had the highest impact on preferences. Among grade III/IV side effects, motor neuropathy, nausea/vomiting, and myalgia made the most difference. An oral twice-daily regimen was most preferred; however, patients were willing to receive an intravenous regimen relative to oral to avoid an increased risk of 5% in the majority of side effects. Avoiding an increased chance of grade III/IV motor neuropathy was associated with willingness to tolerate one of the least preferred administration schedules. Conclusion. This study identified relative preferences among both mild/moderate to severe side effects from the patient perspective. Patients appear to be willing to make trade-offs between side effects and different regimens. These findings may help to inform medical decision-making processes. |
| Databáze: | OpenAIRE |
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