Sensitization to peanut, egg or pets is associated with skin barrier dysfunction in children with atopic dermatitis
| Autor: | Elisabet Johannson, Jocelyn M. Biagini, Gowtham Atluri, Asel Baatyrbek Kyzy, Michael G. Sherenian, Lisa J Martin, John Kroner, Hua He, Arjun Kothari, Gurjit K. Khurana Hershey |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Immunology Population Filaggrin Proteins medicine.disease_cause Article Dermatitis Atopic Machine Learning Allergic sensitization 03 medical and health sciences Dogs 0302 clinical medicine Allergen medicine Animals Calgranulin B Humans Immunology and Allergy Calgranulin A Peanut Hypersensitivity Egg Hypersensitivity education Sensitization Skin Skin Tests education.field_of_study business.industry Infant Aeroallergen Pets Atopic dermatitis medicine.disease Water Loss Insensible 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Child Preschool Cohort Cats Female business Filaggrin |
| Zdroj: | Clin Exp Allergy |
| ISSN: | 1365-2222 0954-7894 |
| DOI: | 10.1111/cea.13866 |
| Popis: | BACKGROUND: Children with atopic dermatitis (AD) are often sensitized to food and aeroallergens, but sensitization patterns have not been analysed with biologic measures of disease pathogenicity. OBJECTIVE: We sought to define allergen sensitization grouping(s) using unbiased machine learning and determine their associations with skin filaggrin (FLG) and transepidermal water loss (TEWL) (assesses skin barrier integrity), S100A8 and S100A9 expression (assesses skin inflammation) and AD severity. METHODS: We studied 400 children with AD in the Mechanisms of Progression from Atopic Dermatitis to Asthma in Children (MPAACH) cohort to identify groupings of food and aeroallergen sensitizations. MPAACH is a paediatric AD cohort, aged 1–2, recruited through hospital/community settings between 2016 and 2018. We analysed these groupings' associations with AD biomarkers: skin FLG, S100A8 and S100A9 expression, total IgE, TEWL and AD severity. RESULTS: An unbiased machine learning approach revealed five allergen clusters. The most common cluster (N = 131), SPT(PEP,) had sensitization to peanut, egg and/or pets. Three low prevalence clusters, which included children with allergen sensitization other than peanut, egg or pets, were combined into SPT(Other). SPT(NEG) included children with no sensitization(s). SPT(PEP) children had higher median non-lesional TEWL (16.9 g/m(2)/h) and IgE (90 kU/L) compared with SPT(OTHER) (8.8 g/m(2)/h and 24 kU/L; p = .01 and p < .001) and SPT(NEG) (9 g/m(2)/h and 26 kU/L; p = .003 and p < .001). SPT(PEP) children had lower median lesional (0.70) and non-lesional (1.09) FLG expression compared with SPT(OTHER) (lesional: 0.9; p = .047, non-lesional: 1.78; p = .01) and SPT(NEG) (lesional: 1.47; p < .001, non-lesional: 2.21; p < .001). There were no differences among groupings in S100A8 or S100A9 expression. CONCLUSIONS AND CLINICAL RELEVANCE: In this largely clinic-based cohort of young children with AD, allergic sensitization to peanut, egg, cat or dog was associated with more severe disease and skin barrier function but not markers of cutaneous inflammation. These data need replicating in a population-based cohort but may have important implications for understanding the interaction between AD and allergic sensitization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|