Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats
| Autor: | Mouloud Lamtai, Abdelhalem Mesfioui, Hajar Benmhammed, Sofia Azirar, Aboubaker El Hessni, Ali Ouichou, Oussama Zghari, Abdelghafour El Hamzaoui, Sihame Ouakki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Morris water navigation task Hippocampal formation medicine.disease_cause Neuroprotection Melatonin Superoxide dismutase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nickel Memory Internal medicine hemic and lymphatic diseases medicine Hippocampus (mythology) 030304 developmental biology Anxiety-like 0303 health sciences biology Chemistry Endocrinology Oxidative stress biology.protein Original Article Depression-like 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Environmental Analysis, Health and Toxicology |
| ISSN: | 2671-9525 |
| Popis: | The present work is carried out to explore the neuroprotective potential of Melatonin(Mel), on Ni-induced neurobehavioral, biochemical and histological alterations in male and female rats. The rats were intraperitoneally administered by nickel chloride (NiCl2, 1 mg/kg) and Mel (4 mg/kg) for 60 days. A neurobehavioral assessment was performed. Biochemical determinations of oxidative stress (OS) levels, and histological analysis of hippocampal tissues were also performed. Results showed that Nickel (Ni) treatment increased anxiety-like and depression-like behavior in rats. Besides, cognitive behavior on the Morris water maze was compromised following Ni treatment. Alongside this, Ni elevated hippocampal OS markers like lipid peroxidation and nitric oxide formation with a decrease in superoxide dismutase and catalase activities. Histological observations confirmed these results. Significantly, Mel administration alleviated neurobehavioral changes in Ni-treated rats of both genders. Also, Mel attenuated Ni-induced OS and increased the activities of antioxidant enzymes. The histopathological studies in the hippocampus supported that Mel markedly reduced the Ni-induced neuronal loss. In conclusion, this study suggests that Mel has a neuroprotective effect against Ni-induced neurobehavioral alterations, which may be related to lowering OS in the hippocampus. |
| Databáze: | OpenAIRE |
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