The effects of idazoxan on reaction times, eye movements and the mood of healthy volunteers and patients with upper respiratory tract illnesses
| Autor: | David J. Nutt, Sue Wilson, Neil Rich, Jayne E Bailey, Carolyn Frances Brice, Wendy Sturgess, Claire Collison, Andrew Paul Smith |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system Eye Movements medicine.medical_treatment Placebo Malaise Norepinephrine 03 medical and health sciences 0302 clinical medicine Double-Blind Method Idazoxan Oral administration Reaction Time medicine Humans heterocyclic compounds Pharmacology (medical) Respiratory Tract Infections Adrenergic alpha-Antagonists Pain Measurement Pharmacology Brain 030227 psychiatry Stimulant Affect Psychiatry and Mental health medicine.anatomical_structure Mood nervous system Anesthesia medicine.symptom Psychomotor disorder Psychology 030217 neurology & neurosurgery Respiratory tract medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | An experiment was carried out to determine whether idazoxan, a drug which increases the turnover of central noradrenaline, removes the malaise (reduced alertness, slower psychomotor performance) associated with upper respiratory tract illness (URTI). Eighty-one volunteers were tested when healthy and 17 returned to the laboratory when they developed URTIs. Those who remained healthy were then recalled as a control group. Volunteers were tested before and after receiving either idazoxan (40 mg) or a lactose placebo. Idazoxan removed the URTI-induced slowing in a simple reaction time task and this group performed at a comparable level to the healthy group. No significant stimulant effect of idazoxan was found in the healthy subjects. The results suggest that at least part of the malaise induced by URTIs may reflect reductions in central noradrenaline and that this can be reversed by compounds such as idazoxan. |
| Databáze: | OpenAIRE |
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