Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance
| Autor: | Isabel Diez-Santos, Natassja G. Bush, Anthony Maxwell, Lauren R Abbott |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
antibiotic resistance
medicine.drug_class Antibiotics Pharmaceutical Science Review Quinolones DNA gyrase Analytical Chemistry Microbiology topoisomerases lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Antibiotic resistance lcsh:Organic chemistry Drug Discovery Animals Humans Medicine supercoiling Physical and Theoretical Chemistry fluoroquinolones 030304 developmental biology antibacterials 0303 health sciences Bacteria biology 030306 microbiology business.industry Topoisomerase Organic Chemistry Drug Resistance Microbial Quinolone biology.organism_classification Anti-Bacterial Agents DNA topology chemistry Chemistry (miscellaneous) biology.protein Molecular Medicine DNA supercoil business DNA |
| Zdroj: | Molecules, Vol 25, Iss 5662, p 5662 (2020) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase and DNA topoisomerase IV, where they stabilise a covalent enzyme-DNA complex in which the DNA is cleaved in both strands. This leads to cell death and turns out to be a very effective way of killing bacteria. However, resistance to FQs is increasingly problematic, and alternative compounds are urgently needed. Here, we review the mechanisms of action of FQs and discuss the potential pathways leading to cell death. We also discuss quinolone resistance and how quinolone treatment can lead to resistance to non-quinolone antibiotics. |
| Databáze: | OpenAIRE |
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