Real-Time High-Resolution Tandem Mass Spectrometry Identifies Furan Derivatives in Exhaled Breath

Autor:	Guillermo Vidal-de-Miguel, César Barrios-Collado, Renato Zenobi, Lukas Bregy, Diego García-Gómez
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Chromatography chemistry Breath Tests Tandem Mass Spectrometry Furan High resolution Tandem mass spectrometry Furans Chromatography High Pressure Liquid 3. Good health Analytical Chemistry
Zdroj:	Analytical Chemistry, 87 (13) Analytical chemistry ResearcherID
Popis:	The identification of chemical compounds in exhaled human breath is promising in the search for new biomakers of diseases. However, the analytical techniques used nowadays are not capable of achieving a robust identification, especially in real-time analysis. In this work, we show that real-time high-resolution tandem mass spectrometry (HRMS/MS) is suitable for the identification of biomarkers in exhaled breath. Using this approach, we identified a number of furan derivatives, compounds found in the exhalome whose nature and origin are not yet clearly understood. It is also shown that the combination of HRMS/MS with UHPLC allowed not only the identification of the furan derivatives but also the proper separation of their isomeric forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a29bd525e9c4c97f3b806d96e68fd0 https://hdl.handle.net/20.500.11850/103100 Zobrazit plný text záznamu