Comparison of FP-CIT SPECT with F-DOPA PET in patients with de novo and advanced Parkinson's disease

Autor: S Jonkman, Silvia Eshuis, RP Maguire, Philip L. De Jager, Klaus L. Leenders
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Adult
Male
Parkinson's disease
Dopamine
Single-photon emission computed tomography
FP-CIT SPECT
F-DOPA PET
DOPAMINERGIC SYSTEM
POSITRON-EMISSION-TOMOGRAPHY
AGE
Image Processing
Computer-Assisted
medicine
Humans
Radiology
Nuclear Medicine and imaging
STRIATAL UPTAKE
dopamine transporter
IN-VIVO
Aged
Dopamine transporter
Tomography
Emission-Computed
Single-Photon
DECREASE
Dopamine Plasma Membrane Transport Proteins
DECLINE
IODINE-123-BETA-CIT
medicine.diagnostic_test
biology
business.industry
Putamen
Dopaminergic
Membrane Transport Proteins
Parkinson Disease
General Medicine
Middle Aged
medicine.disease
TRANSPORTERS
Dihydroxyphenylalanine
Positron emission tomography
Positron-Emission Tomography
Cardiovascular agent
Dopa Decarboxylase
biology.protein
Female
EARLY-STAGE
business
Nuclear medicine
Tropanes
medicine.drug
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging, 33(2), 200-209. SPRINGER
ISSN: 1619-7070
Popis: Purpose: Diagnosis of Parkinson's disease (PD) can be difficult. F-DOPA PETis able to quantify striatal dopa decarboxylase activity and storage capacity of F-dopamine, but is expensive and not generally available. FP-CIT binds to the dopamine transporter, and FP-CIT SPECT is cheaper and more widely available, but has a lower resolution. The aim of this study was to compare these two methods in the same patients with different stages of PD to assess their power in demonstrating deficits of the striatal dopaminergic system.Methods: Thirteen patients with de novo PD and 17 patients with advanced PD underwent FP-CIT SPECT and static F-DOPA PET. After data transfer to standard stereotactic space, a template with regions of interest was used to sample values of the caudate, putamen and an occipital reference region. The outcome value was striato-occipital ratios. Patients were clinically examined in the "off state" (UPDRS-III and H&Y stage).Results: Good correlations were found between striatal F-DOPA uptake and striatal FP-CIT uptake ( r= 0.78) and between putaminal F-DOPA uptake and putaminal FP-CIT uptake ( r= 0.84, both pConclusion: FP-CIT values correlate well with F-DOPA values. Both methods correlate moderately with motor scores and are equally able to distinguish patients with advanced PD from patients with de novo PD.
Databáze: OpenAIRE
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