Synchronizing nuclear import of ribosomal proteins with ribosome assembly
| Autor: | Gert Bange, Stefan Amlacher, Yoshihiro Yoneda, Irmgard Sinning, Bettina Bradatsch, Jun Katahira, Yutaka Ogawa, Dagmar Pratte, Dieter Kressler, Ed Hurt, Goran Stjepanovic, Daniela Strauß |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Ribosomal Proteins Saccharomyces cerevisiae Proteins Protein Conformation Molecular Sequence Data Active Transport Cell Nucleus Saccharomyces cerevisiae Biology Chaetomium Crystallography X-Ray Ribosome Ribosome assembly Fungal Proteins 03 medical and health sciences 5S ribosomal RNA 0302 clinical medicine Ribosomal protein Amino Acid Sequence 030304 developmental biology Cell Nucleus 0303 health sciences Multidisciplinary Base Sequence RNA Ribosomal 5S RNA-Binding Proteins RNA Fungal Ribosomal RNA beta Karyopherins 3. Good health Cell biology Protein Structure Tertiary Biochemistry Cytoplasm Nucleoporin Nuclear transport Protein Multimerization Ribosomes 030217 neurology & neurosurgery Protein Binding |
| Zdroj: | Science (New York, N.Y.). 338(6107) |
| ISSN: | 1095-9203 |
| Popis: | Symportin Synchrony Ribosomes, the macromolecular machines responsible for protein synthesis, function in the cytoplasm but are assembled in the nucleus. Ribosomal proteins must be imported into the nucleus, but how this is coordinated with assembly is unclear. Kressler et al. (p. 666 ) report that two 5S rRNA binding proteins are coimported into the nucleus. They identify a transport adaptor, which they term symportin (Syo1), that binds simultaneously to Rpl5 and Rpl11. Syo1 also interacts with the import receptor Kap104, which facilitates import of the Syo1-Rpl5-Rpl11 complex. Synchronous nuclear transport may be more generally used to coordinate assembly processes. |
| Databáze: | OpenAIRE |
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