The role of biofactors in the prevention and treatment of age‐related diseases
| Autor: | Ovidiu Alin Stirban, Jana Golombek, Maren C. Podszun, Sarah Egert, Jan Frank, Hans-Georg Classen, Gunter P. Eckert, Jacqueline A. Pettersen, Maria Wallert, Sascha Venturelli, Klaus Kisters, Rima Obeid, Stefan Lorkowski |
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| Rok vydání: | 2021 |
| Předmět: |
Dietary Fiber
0301 basic medicine medicine.medical_specialty Clinical Biochemistry Population Biochemistry Epigenesis Genetic 03 medical and health sciences Folic Acid 0302 clinical medicine Non-alcoholic Fatty Liver Disease Neoplasms Diabetes mellitus Fatty Acids Omega-3 Nonalcoholic fatty liver disease Diabetes Mellitus medicine Vitamin D and neurology Humans Vitamin E Dementia Thiamine Vitamin D education Intensive care medicine Aged education.field_of_study Thioctic Acid business.industry Incidence (epidemiology) Cancer General Medicine medicine.disease Micronutrient 030104 developmental biology Cardiovascular Diseases 030220 oncology & carcinogenesis Dietary Supplements Molecular Medicine business |
| Zdroj: | BioFactors. 47:522-550 |
| ISSN: | 1872-8081 0951-6433 |
| DOI: | 10.1002/biof.1728 |
| Popis: | The present demographic changes toward an aging society caused a rise in the number of senior citizens and the incidence and burden of age-related diseases (such as cardiovascular diseases [CVD], cancer, nonalcoholic fatty liver disease [NAFLD], diabetes mellitus, and dementia), of which nearly half is attributable to the population ≥60 years of age. Deficiencies in individual nutrients have been associated with increased risks for age-related diseases and high intakes and/or blood concentrations with risk reduction. Nutrition in general and the dietary intake of essential and nonessential biofactors is a major determinant of human health, the risk to develop age-related diseases, and ultimately of mortality in the older population. These biofactors can be a cost-effective strategy to prevent or, in some cases, even treat age-related diseases. Examples reviewed herein include omega-3 fatty acids and dietary fiber for the prevention of CVD, α-tocopherol (vitamin E) for the treatment of biopsy-proven nonalcoholic steatohepatitis, vitamin D for the prevention of neurodegenerative diseases, thiamine and α-lipoic acid for the treatment of diabetic neuropathy, and the role of folate in cancer epigenetics. This list of potentially helpful biofactors in the prevention and treatment of age-related diseases, however, is not exhaustive and many more examples exist. Furthermore, since there is currently no generally accepted definition of the term biofactors, we here propose a definition that, when adopted by scientists, will enable a harmonization and consistent use of the term in the scientific literature. |
| Databáze: | OpenAIRE |
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