Subgrouping Autism Based on Symptom Severity Leads to Differences in the Degree of Convergence Between Core Feature Domains
| Autor: | Kathryn E. Unruh, Robin L. Shafer, James W. Bodfish, Allison Whitten |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Parents Adolescent Autism Spectrum Disorder Severity of Illness Index behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine mental disorders Developmental and Educational Psychology Feature (machine learning) medicine Humans 0501 psychology and cognitive sciences Child Intelligence Tests Genetic heterogeneity 05 social sciences Symptom severity medicine.disease Degree (music) Core (game theory) Autism spectrum disorder Child Preschool Autism Female Convergence (relationship) Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology Clinical psychology |
| Zdroj: | Journal of Autism and Developmental Disorders. 48:1908-1919 |
| ISSN: | 1573-3432 0162-3257 |
| Popis: | Existing models of autism spectrum disorder (ASD) disagree as to whether the core features should be conceptualized as convergent (related) or divergent (unrelated), and the few previous studies addressing this question have found conflicting results. We examined standardized parent ratings of symptoms from three domains (social, communication, repetitive behaviors) in large samples of typically developing children, children with ASD, and ASD subgroups. Our results suggest that the most evidence for divergence lies in typically developing children and lower severity ASD cases, while more evidence for convergence is found in a subset of cases with more severe impairment on any core feature. These results highlight the importance of subgrouping ASD given the degree of phenotypic heterogeneity present across the autism spectrum. |
| Databáze: | OpenAIRE |
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